Background:Our previous study shows that the empirical formula of Chinese medicine Jianpi-yangwei decoction(JYD)can improve the quality of life in patients with
选择L-半胱氨酸为中心分子,设计合成了两亲性载体mPEG-Cys-AFC偶联体,其中4-三氟甲基-6-氨基香豆素(AFC)为模型药物.通过1 H NMR、13 C NMR和MALDI-TOF-MASS对化合物结构进行了表征.采用水溶法制备了胶束,利用芘荧光探针法确定了临界胶束浓度(CMC)为92.8mg/L,测得胶束的平均粒径为141.1nm,Zeta电位为-6.11mV.经测定表明,在PGA酶作