本文述敍了制取維生素B_1的改进方法。縮合制得的2—甲基-4-氨基-5-乙酰氨甲基嘧啶,不通过用氯化氢醇液水解得双盐酸盐,而是将2—甲基-4-氨基-5-乙酰氨甲基嘧啶以硷水解直接制得二胺硷,然后再与CS_2、NH_4OH,γ-氯代-γ-乙酰丙醇乙酯縮合而制得SB_1这样即縮短了生产工序。本文所附的实验方法可供药物化学实驗用。 This article describes the preparation of vitamin B_1 improved method. The 2-methyl-4-amino-5-acetylaminomethylpyrimidine obtained by the condensation was not converted to the dihydrochloride by hydrolysis with an alcoholic hydrogen chloride but instead 2-methyl-4-amino-5-acetamide Methyl pyrimidine alkaline hydrolysis directly obtained diamine base, and then with CS_2, NH_4OH, γ-chloro-γ-acetyl propanol ethyl ester condensation obtained SB_1 This shortens the production process. The experimental method attached to this article is for use in pharmaceutical chemistry experiments.