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目的:探讨血液流变学指标和组织因子促凝活性指标对慢性脑血管病早期诊断和疗效监测的作用。方法:对77例慢性脑血管病患者(慢性脑血管病组)和40例健康体检者(对照组)检测全血黏度等6项参数及组织因子促凝活性,并比较2组各项指标变化情况。结果:慢性脑血管病组患者全血黏度等6项指标及组织因子促凝活性均较对照组高(P<0.05)。治疗后血液流变学指标有明显改善,其中红细胞聚集指数、纤维蛋白原和组织因子促凝活性降低明显(P<0.01)。结论:血液流变学指标和组织因子促凝活性对慢性脑血管病早期诊断及治疗效果判断具有重要临床意义。
Objective: To investigate the effect of hemorheology index and tissue factor procoagulant activity on the early diagnosis and curative effect of chronic cerebrovascular disease. Methods: Sixty-seven patients with chronic cerebrovascular disease (chronic cerebrovascular disease group) and 40 healthy subjects (control group) were tested for six parameters of whole blood viscosity and tissue factor procoagulant activity. The changes of the indexes in two groups were compared Happening. Results: Six indicators of whole blood viscosity and procoagulant activity of tissue factor in patients with chronic cerebrovascular disease were higher than those in control group (P <0.05). After treatment, the indexes of hemorheology were significantly improved, of which erythrocyte aggregation index, fibrinogen and tissue factor procoagulant activity decreased significantly (P <0.01). Conclusion: Hemorheological indexes and tissue factor procoagulant activity have important clinical significance in the early diagnosis and treatment of chronic cerebrovascular disease.