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目的:比较金玄痔科熏洗散有效部位新制剂与原制剂的抗炎镇痛作用,以期为该传统中药制剂点的工艺改革提供实验依据。方法:采用二甲苯所致小鼠耳廓肿胀,蛋清所致大鼠足跖肿胀等急性炎症模型,比较观察金玄痔科熏洗散有效部位新制剂与原制剂的抗炎作用;采用热板至痛实验观察其镇痛作用。结果:金玄痔科熏洗散有效部位新制剂能明显抑制二甲苯所致小鼠耳郭肿胀和蛋清所致大鼠足跖肿胀;明显提高热板所致小鼠的痛阈。结论:金玄痔科熏洗散有效部位新制剂的抗炎镇痛作用优于原制剂,且具有有效物质基础明确、质量控制标准完善、临床使用剂量减少等优势。
OBJECTIVE: To compare the anti-inflammatory and analgesic effect of the new preparation and the original preparation of the effective part of Jinxuan Hemorrhoid Washing Powder, in order to provide the experimental evidence for the process reform of this traditional Chinese medicine preparation. Methods: Acute inflammation model induced by swelling of auricle of mouse induced by xylene and swollen soles of rats induced by albumen was observed. The anti-inflammatory effects of the new preparation and the original preparation of the effective part of Jinxuan Hemorrhoid Washing Powder were observed. Pain test to observe the analgesic effect. Results: The new preparation of effective part of Jinxuan Hemorrhoid Washing Powder can significantly inhibit the swelling of the auricles of mice induced by xylene and the swelling of foot in rats induced by albumen, and obviously increase the pain threshold of mice induced by hot plate. Conclusion: The anti-inflammatory and analgesic effect of the new preparation of Jinxuan Hemorrhoid Washing Powder effective part is better than that of the original preparation, and has the advantages of clear effective substance base, perfect quality control standard and reduced dosage for clinical use.