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目的探讨可溶型不规则趋化因子(sFKN)和肿瘤坏死因子-α(TNF-α)在川崎病(KD)患儿血浆中的变化以及与冠状动脉损伤的关系。方法选取2015年6月~2016年12月于我院儿科住院的KD患儿38例,根据心脏超声心动图检查结果分为冠状动脉损伤(CAL)组16例和无冠状动脉损伤(NCAL)组22例;随机选取同期门诊健康体检儿童20例作为对照组。采用酶联免疫吸附法(ELISA)测定各组儿童血浆sFKN、TNF-α水平。结果 KD患儿急性期血浆sFKN、TNF-α水平高于对照组,而亚急性期较急性期则显著降低。KD患儿急性期CAL组血浆sFKN、TNF-α的水平高于NCAL组,亚急性期CAL组仍较NCAL组高,但差异无统计学意义(P>0.05)。相关性分析显示,sFKN与TNF-α在KD患儿急性期成正相关关系。结论 sFKN和TNF-α共同参与了KD血管炎及冠状动脉损伤的形成过程。
Objective To investigate the changes of plasma soluble plasminogen activator (sFKN) and tumor necrosis factor-α (TNF-α) in children with Kawasaki disease (KD) and their relationship with coronary artery injury. Methods Thirty-eight KD children hospitalized in our pediatric department from June 2015 to December 2016 were divided into 16 cases with coronary artery injury (CAL) and no coronary artery lesion (NCAL) according to the echocardiography results Twenty-two patients were randomly selected from 20 healthy children in the same period as the control group. Serum sFKN and TNF-α levels were measured by enzyme-linked immunosorbent assay (ELISA). Results The plasma levels of sFKN and TNF-α in acute KD children were significantly higher than those in the control group, while those in the acute sub-acute phase were significantly lower than those in the control group. The plasma levels of sFKN and TNF-α in CAL children with acute KD were higher than those in NCAL patients, and those in sub-acute CAL patients were still higher than those in NCAL patients. However, the difference was not statistically significant (P> 0.05). Correlation analysis showed that, sFKN and TNF-α in children with acute KD positive correlation. Conclusion sFKN and TNF-α participate in the formation of KD vasculitis and coronary artery injury.