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目的 探讨胰腺癌综合治疗中大剂量放射治疗对化学治疗可能产生的影响。方法 采用高效液相色谱法（ HPLC）分别测定大白鼠经 10Gy 60Co胰腺外照射后第 2、 4、 6、 8、 10天时，静脉注射 (93.75mg/kg)5－氟尿嘧啶在胰腺组织中的穿透比（ PR）。同时行胰腺病理检查。结果 10 Gy胰腺外照射后， PR随时间的推移而增加，第 6天达高峰， PR=0.8300± 0.1662（ P
Objective To investigate the possible effects of high-dose radiation therapy on chemotherapy in the treatment of pancreatic cancer. Methods High-performance liquid chromatography (HPLC) was used to detect the levels of 5-Fluorouracil in pancreatic tissues at 2, 4, 6, 8 and 10 days after intravenous injection of 93.75 mg / Permeability (PR). Pancreas at the same time pathological examination. Results After 10 Gy external pancreas irradiation, PR increased with time and reached the peak on the 6th day, PR = 0.8300 ± 0.1662 (P