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目的探索用过硫酸铵做为氧化剂测定尿碘方法的适宜因素。方法尿样经过硫酸铵消化后，又经过Ｓａｎｄｅｌ－Ｋｏｌｔｈｏｆ反应，最后用分光光度法测定尿碘含量。结果该方法的灵敏度为７μｇ／Ｌ；批间和批内变异系数均小于１０％；硫氰酸钾、维生素Ｃ和维生素Ｂ２对方法均无干扰；加入不同浓度标准后回收率在１００％～１０３％之间；与氯酸法有显著的线性相关关系（Ｐ＜０．０１）。结论该方法具有无爆、消化时无有害气体溢出、经济、方便等优点，特别适合发展中国家用于碘缺乏病监测。
Objective To explore the suitable factors for the determination of urinary iodine using ammonium persulfate as oxidant. Methods Urine samples were digested with ammonium sulfate and then subjected to Sandel-Kolthof reaction. The urinary iodine content was determined spectrophotometrically. Results The sensitivity of the method was 7μg / L; the coefficients of variation between batches and batches were all less than 10%; potassium thiocyanate, vitamin C and vitamin B2 did not interfere with the method. The recoveries ranged from 100% to 103 %; There was a significant linear correlation with the chlorate method (P <0.01). Conclusion The method has no explosion, no harmful gas spillage during digestion, economy, convenience and other advantages, especially for developing countries for the monitoring of iodine deficiency disorders.