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目的探讨川崎病急性期血液黏度变化的意义。方法观察20例川崎病急性期患儿血液黏度的变化,并对红细胞聚集性、血小板聚集性、血浆纤维蛋白原、α2球蛋白等影响因素进行了分析。结果川崎病急性期全血低切黏度增高(P<0.01),红细胞聚集性、血小板聚集性增加(P<0.01,P<0.05),血浆黏度、血浆纤维蛋白原和α2球蛋白均增高(P<0.05,P<0.05,P<0.01).全血低切黏度随红细胞聚集性增强而增高,与血浆黏度和血小板聚集性呈正相关(r=0.50,r=0.45,P均<0.05)。红细胞聚集性与血浆纤维蛋白原、α2球蛋白呈正相关(r=0.62,r=0.84,P均<0.01),血浆黏度与纤维蛋白原、α2球蛋白呈正相关(r=0.74,r=0.56,P均<0.01)。结论川崎病急性期红细胞聚集性、血小板聚集性和血浆黏度增高导致全血低切黏度增加,对临床有指导意义。
Objective To explore the significance of changes of blood viscosity in acute Kawasaki disease. Methods The changes of blood viscosity in 20 children with acute Kawasaki disease were observed and the influencing factors such as erythrocyte aggregation, platelet aggregation, plasma fibrinogen and α2 globulin were analyzed. Results In the acute stage of Kawasaki disease, the low blood viscosity of whole blood was increased (P <0.01), the aggregation of erythrocytes and platelet aggregation (P <0.01, P <0.05) and plasma viscosity, plasma fibrinogen and α2 globulin were increased <0.05, P <0.05, P <0.01) .However, whole blood low shear viscosity increased with the increase of erythrocyte aggregation and positively correlated with plasma viscosity and platelet aggregation (r = 0.50, r = 0.45, P <0.05). Erythrocyte aggregation was positively correlated with plasma fibrinogen and α2 globulin (r = 0.62, r = 0.84, P <0.01), and plasma viscosity was positively correlated with fibrinogen and α2 globulin (r = 0.74, r = 0.56, P <0.01). Conclusion Acute Kawasaki disease erythrocyte aggregation, platelet aggregation and increased plasma viscosity led to the increase of low blood viscosity of whole blood, which is of clinical significance.