非酒精性脂肪性肝病(NAFLD)是发达国家引起肝功能异常最常见的原因,治疗的重点在于阻止疾病的进展,去除引起代谢综合征的危险因素,如肥胖、胰岛素抵抗及血脂紊乱等。随着NAFLD的发病机制逐渐揭示,可选择的治疗方法除减肥外,药物治疗有抗氧化剂、胰岛素增敏剂、降脂药和肝脏保护剂。本文重点对药物治疗的进展做一综述。 Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in developed countries. The focus of treatment is to prevent the progression of the disease and remove the risk factors of metabolic syndrome such as obesity, insulin resistance and dyslipidemia. With the pathogenesis of NAFLD gradually revealed, alternative treatment methods in addition to weight loss, the drug treatment with antioxidants, insulin sensitizers, lipid-lowering drugs and liver protective agent. This article focuses on the progress of drug treatment is reviewed.