超顺磁性氧化铁纳米粒(SPIO)因其独特优越的理化性能受到人们日益广泛关注。随着纳米技术与生物医学结合的日益深入,其在生物标记与分离、核磁共振显影、药物载体及疾病诊断与治疗等方面显示出广泛应用前景,尤其对其进行功能化修饰更成为研究热点。骨髓间充质干细胞(BMSCs)不仅可分化为造血基质细胞,还可分化为许多造血以外的组织,特别 Superparamagnetic iron oxide nanoparticles (SPIO) are attracting more and more attention due to their unique physical and chemical properties. With the development of nanotechnology and biomedicine, it has been widely applied in biomarker and separation, NMR imaging, drug carrier and disease diagnosis and treatment. Especially, functional modification has become a research hotspot. Bone marrow mesenchymal stem cells (BMSCs) not only differentiate into hematopoietic stromal cells, but also differentiate into many tissues other than hematopoiesis, especially