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作者报告在严重类风湿关节炎时环孢素的多中心研究中,患者应用环孢素和双氯高灭酸(diclofenac)这两种药相互作用的肾毒性。在这项公开研究中,104例患者接受环孢素,开始剂量2.5mg/kg/d,根据反应和毒性增到最大剂量为5mg/kg/d,为期12个月。其中20例用环孢素和双氯高灭酸两种药,7例有高度相互作用的可能性(即是在单独撤除双氯高灭酸时血清肌酐、血清钾和血压得到校正);9例有相互作用的可能性(即药物剂量仍未改变,或两种药停用或同时减小剂量);3例用药6个月或以上没有相互作用;1例由于头痛用药不到1个月退出本研究,未发现相互作用。
The authors report that in patients with multiple-center studies of cyclosporine in patients with severe rheumatoid arthritis, patients are using nephrotoxicity in the interaction of cyclosporine and diclofenac. In this open study, 104 patients received cyclosporine at a starting dose of 2.5 mg / kg / day, up to a maximum dose of 5 mg / kg / day for 12 months, based on response and toxicity. Of these, 20 had cyclosporine and diclofenac, and seven had a high probability of interaction (ie, serum creatinine, serum potassium and blood pressure were corrected for diclofenac alone); 9 For example, there is a possibility of interaction (ie, the dosage of the drug has not changed or the two drugs are discontinued or the dose is reduced at the same time); 3 patients did not interact for 6 months or more; 1 patient died of headache for less than 1 month Withdrawal from the study revealed no interaction.