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选择HBeAg阴性慢性肝炎患者135例,随机分为3组,分别用中药强肝汤、西药拉米夫定以及强肝汤与拉米夫定联合治疗,观察3组在治疗前后HBV-DNA和ALT的变化;主要自觉症状(乏力、纳差、腹胀和肝区不适)的变化;治疗48周YMDD出现的情况以及在停药后24周3组持续应答情况。经统计学分析得出中药强肝汤能提高拉米夫定的治疗效果,减少停药后复发和治疗过程中出现YMDD,从而提高了这类患者的疗效。
135 patients with HBeAg-negative chronic hepatitis were randomly divided into 3 groups, treated with Qianggan Decoction, lamivudine plus Qianggan Decoction and lamivudine respectively. The changes of HBV-DNA and ALT ; Changes of main symptoms (fatigue, anorexia, abdominal distension and liver discomfort); the occurrence of YMDD after 48 weeks of treatment and the sustained response of group 3 at 24 weeks after drug withdrawal. The statistical analysis shows that Qianggan Decoction can improve the therapeutic effect of lamivudine and reduce the emergence of YMDD during the relapse and treatment after discontinuation, thus improving the curative effect of these patients.