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抗癫痫药物可在机体引起一种以皮疹为典型表现的超敏反应。传统观点认为它与抗癫痫药物的活性中间产物及环氧化物水解酶的缺乏有关,新近研究表明T细胞在这种皮肤超敏反应中起到了重要作用。本文将从细胞免疫、酶与解毒、T细胞表现型多样性等方面进一步综述关于此类皮肤超敏反应的发病机制。
Antiepileptic drugs cause a hypersensitivity reaction typical of a rash in the body. The traditional view that it is associated with the lack of epilepsy active intermediates and epoxide hydrolases, recent studies have shown that T cells play an important role in this skin hypersensitivity. This article reviews the pathogenesis of such skin hypersensitivity in terms of cellular immunity, enzymes and detoxification, T cell phenotype diversity and other aspects.