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[目的]探讨有机磷农药中毒上消化道黏膜病变的并发症及发病机制。[方法]分析1998年1月~2007年12月58例有机磷农药中毒的临床资料及胃镜检查结果。[结果]所有患者上消化道黏膜显示不同部位不等程度的损伤改变。其中食管炎21例(36.2%),胃炎58例(100%),十二指肠球炎12例(20.7%),2个月后发现溃疡形成1例(1.7%)。[结论]临床除按有机磷农药中毒抢救外,还需予制酸剂、胃黏膜保护剂、止血剂等治疗。
[Objective] To investigate the complications and pathogenesis of upper gastrointestinal mucosal lesions caused by organophosphorus pesticide poisoning. [Method] The clinical data and gastroscopy findings of 58 cases of organophosphorus pesticide poisoning from January 1998 to December 2007 were analyzed. [Results] Upper gastrointestinal mucosa of all patients showed varying degrees of injury changes in different parts. Among them, 21 (36.2%) had esophagitis, 58 (100%) had gastritis, and 12 (20.7%) had duodenal inflammation. One case (1.7%) developed ulceration after 2 months. [Conclusion] In addition to being treated by organophosphorus pesticide poisoning, antacids, gastric mucosal protective agents and hemostatic agents are also needed.