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目的：观察奥美拉唑、阿莫西林、替硝唑三联疗法对十二指肠溃疡的临床治疗效果。方法把近3年来在我科治疗的96例十二指肠溃疡患者随机分为治疗组和对照组，治疗组采用奥美拉唑、阿莫西林、替硝唑组成的三联疗法治疗；对照组采用雷尼替丁、呋喃唑酮、甲硝唑组成的三联疗法治疗。两组患者均于4w后复查胃镜，评定疗效。结果由奥美拉唑、阿莫西林、替硝唑组成的三联疗法治疗十二指肠溃疡有效率显著高于对照组。结论奥美拉唑、阿莫西林、替硝唑三联疗法治疗Hp阳性十二指肠溃疡在对Hp的根除率、溃疡愈合率有明显优势，值得临床推广应用。“,”Objective observation of omeprazole, amoxicil in, tinidazole triple therapy for duodenal ulcer clinical curative ef ect. Methods in recent 3 years in our department for treatment of 96cases of duodenal ulcer patients were randomly divided into treatment group and control group, treatment group with omeprazole, amoxicil in, tinidazole consisting of triple therapy; control group with ranitidine, furazolidone, metronidazole is composed of triple therapy. The 2groups at4 weeks after repeated endoscopy, evaluation of curative ef ect. Results by omeprazole, amoxicil in, tinidazole consisting of triple therapy for the treatment of duodenal ulcer with ef iciency was significantly higher than the control group. Conclusion:tinidazole, amoxicil in, omeprazole triple therapy for the treatment of Hp positive duodenal ulcer in the Hp eradication rate, rate of ulcer healing have obvious advantage, it is worthy of clinical application.