自70年代阐明了免疫球蛋白的结构后,人们又致力于神经系统免疫学的研究,以期了解神经系统的免疫反应是如何产生的,神经系统建立的分子基础是什么。 Buge建立了髓鞘形成的连锁放大的学说,包括四个步骤:①少突神经胶质细胞识别神经元并与其结合;②少突神经胶质细胞增殖;③神经元的再附着和鞘包裹;④多膜模型和髓磷脂的形成。连锁放大过程受一组分子的介导,如神经细胞粘附分子(neural cell adhesion mo-lecular N-CAM)和髓磷脂相关糖蛋白(mye-lin associated glycoprotein MAG)。这组 Since the structure of immunoglobulins was elucidated in the 1970s, people are also devoted to studying the immunology of the nervous system in order to understand how the immune response of the nervous system is produced and what is the molecular basis for the establishment of the nervous system. Buge has established a theory of chain amplification of myelination, including four steps: ① oligodendrocytes recognize and bind neurons; ② oligodendrocyte proliferation; ③ reattachment and sheath sheathing of neurons; ④ multi-membrane model and the formation of myelin. Chain amplification is mediated by a group of molecules, such as neural cell adhesion molecule (N-CAM) and myelin-associated glycoprotein (MAG). This group