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目的 :探讨妊娠早期人巨细胞病毒(HCMV)感染和妇女自然流产的关系。方法 :采用ELISA和PCR分别对40例自然流产妇女和40例人工流产妇女和血清中人巨细胞病毒IgM抗体(HCMV—IgM)胎盘组织中人巨细胞病毒核酸(HCMV—DNA)进行检测。结果 :自然流产组妇女HCMV—IgM检出率为55 %(22/40) ,人工流产组妇女为25 %(10/40) ,自然流产组妇女胎盘组织HCMV—DNA检出率为10 %(4/10) ,而人工流产组为25 %(10/40) ;结论 :HCMV感染可能是早孕期间妇女自然流产的原因之一。
Objective: To investigate the relationship between early pregnancy human cytomegalovirus (HCMV) infection and spontaneous abortion in women. Methods: Human cytomegalovirus nucleic acid (HCMV-DNA) was detected by ELISA and PCR in 40 cases of spontaneous abortion women and 40 cases of abortion women and serum human cytomegalovirus IgM antibody (HCMV-IgM) placental tissue. Results: The detection rate of HCMV-IgM in women with spontaneous abortion was 55% (22/40), that of women with induced abortion was 25% (10/40), and that of HCMV-DNA in women with spontaneous abortion was 10% 4/10) compared with 25% (10/40) in the induced abortion group. CONCLUSIONS: HCMV infection may be one of the causes of spontaneous abortion in women during the first trimester.