论文部分内容阅读
目的探讨应用椎体成形术联合唑来膦酸注射液治疗老年性椎体骨质疏松性压缩骨折的临床效果。方法 2011年3月—2013年8月,从收治骨质疏松性脊柱骨折患者中选取80例老年性骨质疏松脊柱骨折患者分为实验组和对照组,每组40例,两组患者年龄、性别、疼痛视觉模拟评分(VAS)、病程等统计学均无显著性差异(P>0.05),具有可比性。试验组采取椎体成形术配合唑来膦酸进行治疗,对照组采取单一椎体成形术治疗。结果两组患者均获随访,随访时间18~40个月。试验组治疗后1~3 d及12、18个月VAS评分均较术前明显改善(P<0.05),对照组治疗后以上指标均较术前明显改善(P<0.05)。结论椎体成形术治疗效果显著,若同时应用唑来膦酸治疗,可以减少骨量进步丢失,改善骨质疏松情况,进一步降低再骨折发生的风险,是一种治疗老年性骨质疏松脊柱骨折的良好方法。
Objective To investigate the clinical effect of vertebroplasty combined with zoledronic acid injection in the treatment of senile vertebral osteoporotic compression fractures. Methods From March 2011 to August 2013, 80 patients with osteoporotic spondylolisthesis from the patients with osteoporotic spine fracture were divided into experimental group and control group, 40 cases in each group. The age, Gender, pain visual analogue scale (VAS), course of disease and other statistics showed no significant difference (P> 0.05), comparable. The experimental group was treated with vertebroplasty combined with zoledronic acid and the control group with single vertebroplasty. Results Both groups were followed up for 18 to 40 months. The VAS scores of the experimental group at 1 ~ 3 days and at 12 and 18 months after treatment were significantly improved compared with that before operation (P <0.05). The above indexes in the control group were significantly improved after operation (P <0.05). Conclusion Vertebroplasty has a significant therapeutic effect. If zoledronic acid treatment is used simultaneously, it can reduce the loss of bone mass, improve the condition of osteoporosis and further reduce the risk of re-fracture. It is a kind of treatment for senile osteoporotic spine fractures Good method.