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目的 研究两种血卟啉衍生物介导的光动力疗法治疗上消化道癌的近期疗效和不良反应发生情况.方法 回顾性分析1997年2月至2014年10月,上消化道癌患者105例的临床资料,光敏剂采用不同生产年份和不同生产公司的血卟啉衍生物,给药剂量5 mg/kg,于照光前24h静脉滴注.分别应用金蒸气激光和半导体激光作为治疗光源,功率密度100～300 mW/cm2,能量密度100～300 J/cm2.治疗1～4次后对近期疗效以及不良反应进行比较研究.结果 血卟啉衍生物组67例患者,完全效应(complete response,CR)5例(7.25％),明显效应(partial response,PR) 40例(59.7％),稍有效应(mild response,MR) 16例(23.9％),无效(no response,NR)6例(9.0％).血卟啉注射液组38例患者,CR 4例(10.5％),PR 22例(57.9％),MR 7例(18.4％),NR 5例(13.2％).两组病例均未出现严重不良反应.结论 不同时期血卟啉衍生物治疗临床各期上消化道癌疗效相近,不良反应轻、耐受性好,是较好的姑息治疗手段.“,”Objective To study the clinical efficacy and adverse effects of the photodynamic therapy assisted respectively with two hematoporphyrin photosensitizers for upper gastrointestinal tract cancers.Methods Totally 105 patients with upper gastrointestinal cancers in different clinical stages were given photodynamic therapy.Hematoporphyrin derivative and hematoporphyrin injection were used as photosensitizers,which were given intravenously at a dose of 5 mg/kg,24 hours before the irradiation,respectively.Gold vapor laser and diode laser were used as the light source respectively.Their power density was 100 to 300 mW/cm2 and energy density 100 to 300 J/cm2.Results An evaluation of the therapeutic effect of the 67 patients given hematoporphyrin derivative showed that 5 patients (7.5％)had a complete response (CR),40 patients (59.7％) a partial response (PR),16 patients (23.9％) a mild response (MR) and 6 patients (9.0％) no response (NR).The results of the therapeutic effect of the 38 patients given hematoporphyrin injection were:4 CR (10.5％),22 PR (57.9％),7 MR(18.4％) and 5 NR(13.2％).No severe adverse effect was found with any patient in any group.Conclusions The photodynamic therapy using hematoporphyrin derivative or hematoporphyrin injection as a photosensitizer is an effective and safe palliative modality for upper gastrointestinal tract cancers.