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CFW小鼠随机分为二组,实验组:置于内蒙古低碘病区,饲地产饲料和井水(0—0.8μg 碘/L);对照组放在天津,同样饲病区饲料但饮自来水(5—8μg 碘/L)。两种动物共繁殖十代,实验持续了三年。实验组动物表现为运动量减少;脑 DNA 和蛋白质含量下降;血浆 T_4为57.3ng/ml 显著低于对照组(78ng/ml);巩固性条件反射建立延迟,条件反射潜伏期和正确率下降,学习能力显著下降者达12.4%;部分鼠脑电呈慢波。实验组动物所表现的中枢神经系统发育落后显然与长期碘缺乏有关。
CFW mice were randomly divided into two groups, the experimental group: placed in iodine deficiency area in Inner Mongolia, feed the real estate feed and well water (0-0.8μg iodine / L); control group on Tianjin, the same feeding area but drinking tap water (5-8 μg iodine / L). The two animals breed a total of ten generations and the experiment lasted for three years. In the experimental group, the amount of exercise decreased, the content of brain DNA and protein decreased, the plasma T_4 was 57.3ng / ml, which was significantly lower than that of the control group (78ng / ml); the delay of establishing conditioned reflex, the decrease of latency and accuracy of conditioned reflex, Significantly decreased by 12.4%; part of the rat brain was slow wave. The development of central nervous system in experimental group is obviously related to long-term iodine deficiency.