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目的:探讨九味消症汤联合香菇多糖治疗中晚期胃癌的临床疗效、安全性及可能机制。方法:将2014年10月至2015年9月广州医科大学附属广州市第一人民医院收治的90例中晚期胃癌患者随机分成3组:观察组、香菇多糖组和对照组,每组各30例。观察3组患者治疗前后行为状态评分(卡诺夫斯基评分,Karnofsky),中医症状评分,外周血T淋巴细胞亚群、NK细胞变化及不良反应等情况。结果:(1)观察组治疗后中医症状改善情况均优于香菇多糖组及对照组(P<0.05);(2)观察组治疗后T淋巴细胞亚群、NK细胞含量明显高于治疗前,与对照组比较,差异有统计学意义(P<0.05);(3)3组患者治疗后卡诺夫斯基评分比较,差异无统计学意义(P>0.05)。结论:九味消症汤联合香菇多糖治疗中晚期胃癌能明显改善临床症状、提高生活质量,增强患者免疫力,安全有效、不良反应少。
Objective: To investigate the clinical efficacy, safety and possible mechanism of Jiuwei Xiaozheng Decoction combined with lentinan in the treatment of advanced gastric cancer. Methods: From October 2014 to September 2015, 90 patients with advanced gastric cancer admitted to Guangzhou First People’s Hospital of Guangzhou Medical University were randomly divided into three groups: observation group, lentinan group and control group, with 30 cases in each group . The behavioral status scores (Karnofsky score, TCM symptom scores, peripheral blood T lymphocyte subsets, NK cell changes and adverse reactions) were observed before and after treatment in 3 groups. Results: (1) The symptoms of TCM in the observation group were better than lentinan and the control group after treatment (P <0.05); (2) The content of T lymphocyte subsets and NK cells in observation group were significantly higher than those before treatment, Compared with the control group, the difference was statistically significant (P <0.05). (3) There was no significant difference in the Kanofsky scores between the three groups after treatment (P> 0.05). Conclusion: The treatment of middle and late gastric cancer with Jiwei Xiaozheng Decoction combined with lentinan obviously improves clinical symptoms, improves quality of life, enhances patient immunity, is safe and effective, and has few adverse reactions.