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以荧光偏振免疫法和ＥＬＩＳＡ分别测定肾移植患者全血环孢素（Ｃ＿ｓＡ）浓度和血浆可溶性白介素－２受体（＿ｓＩＬ－２Ｒ）水平。稳定移植组、排斥反应组和Ｃ＿ｓＡ毒性组的＿ｓＩＬ－２Ｒ均与正常对照组者有明显差异（Ｐ＜０．０１）；稳定移植组与排斥反应组差异显著（Ｐ＜０．０１），而与Ｃ＿ｓＡ毒性组无明显差异（Ｐ＞０．０５）。全血Ｃ＿ｓＡ浓度与＿ｓＩＬ－２Ｒ，水平无明显相关关系。提示＿ｓＩＬ－２Ｒ是鉴别肾移植患者排斥反应或Ｃ＿ｓＡ毒性的重要指标，对Ｃ＿ｓＡ合理用药有重要意义。
Fluorescence polarization immunoassay and ELISA were used to determine the level of C_sA and the level of soluble interleukin-2receptor (_sIL-2R) in renal allograft recipients. The levels of _sIL-2R in the stable transplantation group, the rejection group and the C_sA toxicity group were significantly different from those in the normal control group (P <0.01), but there was significant difference between the stable transplantation group and the rejection group (P <0.01) No significant difference with C_sA toxicity group (P> 0.05). The concentration of C_sA in whole blood had no significant correlation with the level of _sIL-2R. Tip _sIL-2R is an important indicator of renal allograft rejection or C_sA toxicity, C_sA reasonable medication is important.