论文部分内容阅读
目的探讨原发性胃肠道恶性淋巴瘤的早期诊断及治疗。方法回顾分析1997- 2005年33例原发性胃肠道恶性淋巴瘤(PGIML)患者的临床资料。结果内镜及活检确诊率为44．4％。免疫分型以B细胞为主(90．9％)。全组患者有30例经手术治疗,2例仅行Hp根除术,1例确诊后放弃治疗。术后:单纯手术者21例,2年及以上生存者19例(90．5％);手术加化疗者9例,2年及以上生存者6例(66．7％)。在11例胃黏膜相关淋巴组织(MALT)淋巴瘤中有2例胃MALT淋巴瘤行抗Hp治疗,肿瘤消退或缩小;9例行手术切除,术后未复发。结论PGIML早期诊断较困难,可采取多种诊断手段综合诊断,手术治疗作用尚未肯定,还需进一步随访观察。
Objective To investigate the early diagnosis and treatment of primary gastrointestinal malignant lymphoma. Methods The clinical data of 33 patients with primary gastrointestinal malignant lymphoma (PGIML) from 1997 to 2005 were retrospectively analyzed. Results The diagnosis rate of endoscopy and biopsy was 44.4%. Immunoblotting mainly B cells (90.9%). All patients were treated by surgery in 30 cases, 2 cases only Hp eradication, 1 case gave up treatment after diagnosis. In the postoperative period, there were 21 surgeries and 19 cases (90.5%) with surgeries of 2 years or more. There were 6 cases (66.7%) survived in 2 years and above. In 11 cases of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, 2 cases of gastric MALT lymphoma were treated with anti-Hp therapy and the tumor subsided or contracted. Nine cases underwent surgical resection without recurrence. Conclusion PGIML is difficult to diagnose in the early stage and can be diagnosed by multiple diagnostic methods. The effect of surgical treatment is yet to be confirmed, and further follow-up observation is needed.