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肺泡上皮细胞具有许多重要的功能 ,包括调节表面活性物质代谢、离子转运以及损伤后肺组织修复等[1 ] 。细菌内毒素 (ＬＰＳ)是革兰阴性菌引起的急性肺损伤的重要致病因素。研究表明 ,急性肺损伤可导致肺血管内皮细胞和上皮细胞凋亡[2 ] 。然而 ,ＬＰＳ对肺泡Ⅱ型上皮细胞 (ＡＥ
Alveolar epithelial cells have many important functions, including the regulation of surfactant metabolism, ion transport and lung tissue repair after injury [1]. Bacterial endotoxin (LPS) is an important pathogenic factor of acute lung injury caused by Gram-negative bacteria. Studies have shown that acute lung injury can lead to pulmonary vascular endothelial cells and epithelial cell apoptosis [2]. However, LPS affects alveolar type II cells (AE