论文部分内容阅读
在非胰岛素依赖性糖尿病(NIDDM)病人身上,高血糖是由于胰岛素作用减弱或胰岛素分泌不足所致。这些异常导致肝脏葡萄糖产物的增加和外周组织葡萄糖摄取减少。前者为空腹高血糖的主要原因,后者为饭后高血糖的产生机制。对于NIDDM病人,降低高血糖可通过以下几个途径:(1)减少营养摄入;(2)增加胰岛素分泌;(3)减少肝脏葡萄糖产物;(4)增加外周组织对葡萄糖的摄取。用于治疗NIDDM的口服药是通过一种以上的
In non-insulin-dependent diabetes mellitus (NIDDM) patients, hyperglycemia is due to diminished insulin or insufficient insulin secretion. These abnormalities lead to an increase in hepatic glucose production and a decrease in peripheral tissue glucose uptake. The former is the main reason for fasting hyperglycemia, which is the mechanism of postprandial hyperglycemia. In NIDDM patients, reducing hyperglycemia can be achieved by the following ways: (1) reduce nutritional intake; (2) increase insulin secretion; (3) reduce hepatic glucose products; (4) increase peripheral glucose uptake. Oral drugs for the treatment of NIDDM are administered by more than one