在肿瘤切除手术或肿瘤放射治疗之前对肿瘤引起的周围血管和神经的位移和形变的评估和预测极重要。为模拟良性肿瘤生长对周围血管的影响,用细胞自动机方法模拟肿瘤生长,根据四面体各个顶点是否属于肿瘤体的各种情况对肿瘤几何模型进行网格化、并建立有限元力学模型。对颅底局部连续切片图像重建三维几何模型,提取血管模型并按曲率的相对值自适应细化血管网格,建立薄壳力学模型。通过碰撞检测得到血管和肿瘤的接触点集并施加大小相等方向相反的外力,以模拟生长过程中肿瘤与血管相互力的作用。模拟实验表明,在肿瘤生长过程中血管和肿瘤各自发生弯曲和形变与实际情况基本一致,实验模型可以在一定程度上预测肿瘤生长情况及其对周围组织的影响。 Evaluation and prediction of tumor-induced displacement and deformation of the surrounding blood vessels and nerves prior to tumor excision surgery or tumor radiotherapy is extremely important. To simulate the influence of benign tumor growth on peripheral blood vessels, the cell growth was simulated by the cellular automaton method. The geometric model of the tumor was meshed according to whether each vertex of the tetrahedron belongs to the tumor or not, and the mechanical model of the finite element was established. The three-dimensional geometric model of the skull base partial continuous slice image was reconstructed. The vascular model was extracted and the vascular grids were adaptively refined according to the relative curvature. The thin shell mechanical model was established. By collision detection, the contact points between the blood vessel and the tumor are obtained, and the external forces of the same magnitude and opposite directions are applied to simulate the interaction between the tumor and the blood vessel in the growth process. Simulation experiments show that the bending and deformation of blood vessels and tumors are basically the same with the actual situation in the process of tumor growth. The experimental model can predict the tumor growth and its effect on the surrounding tissues to a certain extent.