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目的：探讨肠道血吸虫病与肠癌发生的关系。方法：应用免疫组织化学ＬＳＡＢ法对结肠血吸虫病并发结肠癌、肠息肉和无血吸虫病的肠癌、肠息肉行ｃｅｒｂＢ２标记并ＡｇＮＯＲ染色。结果：肿瘤细胞中癌基因ｃｅｒｂＢ２表达呈明显异质性；血吸虫病并发肠癌与无血吸虫病的肠癌表达阳性率，两者之间无明显差异（Ｐ＞００５）；血吸虫病肠息肉的表达明显高于无血吸虫病的肠息肉（Ｐ＜００５）。血吸虫病肠息肉ＡｇＮＯＲ／核均显著高于无血吸虫病的肠息肉（Ｐ＜００５）；血吸虫病且ｃｅｒｂＢ２阳性肠息肉和无血吸虫病肠癌之间ＡｇＮＯＲ／核均数无显著差异（Ｐ＞００５）。结论：肠癌中ｃｅｒｂＢ２阳性者具有较强浸润转移能力，血吸虫病肠息肉且ｃｅｒｂＢ２阳性者有癌前病变特征，血吸虫病肠息肉和并发肠癌恶性潜能高。
Objective: To investigate the relationship between intestinal schistosomiasis and the occurrence of intestinal cancer. METHODS: C erbB 2 marker and AgNOR staining were performed in colon cancer and enteric polyps with colon cancer, intestinal polyps, and schistosomiasis, using immunohistochemical LSAB method. Results: The expression of oncogene cerbB2 in tumor cells showed significant heterogeneity; the positive rates of schistosomiasis and schistosomiasis were not significantly different (P>005). The expression of intestinal polyps in schistosomiasis was significantly higher than that in schistosomiasis (P<005). AgNOR/nucleus of schistosomiasis intestinal polyps was significantly higher than that of schistosomiasis (P<005); AgNOR/nucleus average of cerbB2 positive intestinal polyps and schistosomiasis-free schistosomiasis were not Significant difference (P>005). Conclusion: The c-erbB2 positive in colorectal cancer has strong ability of invasion and metastasis. The schistosomiasis intestinal polyps and cerbB2 positive patients have precancerous lesions. The schistosomiasis intestinal polyps and concurrent colorectal cancer have high malignant potential.