设计了一条新颖的 1 苄基哌啶 4 羧酸的合成方法 ,该法以二乙醇胺为起始原料 ,经过氮烃化、氯代、环合和水解四步反应合成了目的物。并对其中的环缩合反应的后处理方法进行了改进。各步反应的操作简单 ,收率较高 ,总收率比文献方法提高了 10 %以上 ,较适用于工业化生产。 A novel method for the synthesis of 1-benzylpiperidine-4-carboxylic acid was designed. The method used diethanolamine as the starting material and synthesized the target compound by four steps of nitrogenation, chlorination, cyclization and hydrolysis. The method of postconditioning of the ring condensation reaction has been improved. Each step of the reaction is simple, high yield, the total yield than the literature method increased by 10% or more, more suitable for industrial production.