论文部分内容阅读
目的探讨结直肠癌前哨淋巴结(sLN)体外定位技术方法及其可行性、准确性和临床价值。方法术中注射异硫蓝方法对45例结肠癌患者进行手术中 SLN 定位的临床研究,手术中取SLN 作快速冰冻病理并与术后常规蜡块病理相对照,观察冰冻病理 SLN 转移与常规病理肠系膜淋巴转移的相关性,及其对肠系膜淋巴结转移的预测价值。结果 45例结直肠癌患者中,42例确定了SLN,SLN 活检成功率93.3%。共检出淋巴结250个,检出 SLN 52个。区域淋巴结病理状况预测的灵敏度为90.4%(20/22),准确性为95.2%[(20+20)/42],SLN 假阴性率为15%(3/20)。结论SLN 检测对判断结直肠癌区域淋巴结转移状况有一定价值,可以用于指导临床手术。
Objective To investigate the method of in situ localization of sentinel lymph node (sLN) in colorectal cancer and its feasibility, accuracy and clinical value. Methods The intraoperative injection of isothiocyanate in 45 cases of colon cancer in patients with SLN localization of clinical research, surgery to take SLN rapid frozen pathology and postoperative routine wax block pathology compared to observe the frozen pathological SLN metastasis and routine pathology Mesenteric lymph node metastasis, and its predictive value of mesenteric lymph node metastasis. Results Among the 45 patients with colorectal cancer, SLN was confirmed in 42 cases and the success rate of SLN biopsy was 93.3%. A total of 250 lymph nodes were detected and 52 SLNs were detected. The sensitivity of regional lymph node biopsy was 90.4% (20/22), accuracy was 95.2% [(20 + 20) / 42], and SLN false negative rate was 15% (3/20). Conclusion The SLN test has certain value in judging the status of lymph node metastasis in colorectal cancer and can be used to guide the clinical operation.