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本项研究以中国广西、贵州引进的香猪为原始素材,通过扩群繁育,全同胞交配,连续闭锁性继代选育过程,培育了遗传背景清楚、生产性能稳定、生长发育一致的中国实验用小型猪。在此基础上,研究了该猪的生长发育规律、解剖组织学结构、生理生化常值、饲养管理特点、疾病监测、净化与控制以及在比较医学中的应用。研究结果表明:中国实验用小型猪具有体积小、繁殖力强、遗传性能稳定、适应范围广泛、饲养管理方便等特点,其某些组织解剖学结构及生理生化常值与人相似,可自发性或高脂膳食诱发产生动脉粥样硬化症(AS)。其AS病变在分布与性质上与人类高度近似,而且在药物防治实验性AS模型方面反应良好;该猪并易于进行口腔医学实验研究。其牙齿用羟基磷酸钙碘仿合剂盖髓后与人牙病理变化一致。牙齿人工龋病损与牙齿自然龋损、人牙人工龋病理表现亦很一致。该猪还适宜做微粒植皮,麻醉试验等研究;是理想的生物学、比较医学、兽医学研究的实验动物。
In this study, Xiang pigs introduced from Guangxi and Guizhou of China were used as raw materials. Through expanding population breeding, all-sibling mating and continuous closed-end succession breeding process, a Chinese experiment with clear genetic background, consistent production performance and consistent growth and development was cultivated With miniature pigs. On this basis, we studied the growth and development of pigs, anatomical structure, physiological and biochemical parameters, feeding and management characteristics, disease monitoring, purification and control and its application in comparative medicine. The results showed that: Chinese experimental miniature piglets are characterized by small size, strong fertility, stable genetic performance, wide range of adaptation and convenient feeding and management. The anatomical structures and physiological and biochemical parameters of some tissues are similar to those of human and spontaneously Or high-fat diet induced atherosclerosis (AS). Its AS lesions are highly similar in distribution and nature to humans, and respond well to the experimental AS model of drug control; this pig is also susceptible to oral medical studies. The teeth with calcium hydroxyphosphate Iodoform agent capping and human tooth pathological changes. Dental artificial dental caries lesions and natural tooth decay, human dental artificial caries pathological performance is also very consistent. The pig is also suitable for micro-particle skin grafting, anesthesia and other studies; is an ideal biological, comparative medicine, veterinary research laboratory animals.