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目的:探讨真实世界婚姻状况是否是影响早期乳腺癌患者生存的因素。方法:针对监测、流行病学和最终结果（SEER）数据库中2012年1月至2015年12月接受治疗的62 845例早期（Tn 1~2Nn 0Mn 0）乳腺癌患者的数据，采用Kaplan-Meier法对年龄、种族、手术情况、T分期、肿瘤不同分化程度、分子分型及婚姻状况7个因素行单因素生存分析，计算5年癌症特异性生存（5-CSS）率；采用多因素Cox比例风险模型分析不同婚姻状况（已婚、未婚、不良婚姻）患者死亡风险。n 结果:单因素分析显示，7个因素均与早期乳腺癌患者的生存相关（均n P<0.001）。多因素分析显示，婚姻状况是患者生存的独立影响因素，其中未婚患者和不良婚姻患者的死亡风险分别为已婚患者的2.014倍（95%n CI 1.714~2.367，n P<0.001）和2.559倍（95%n CI 2.254~2.905，n P<0.001）。在肿瘤分化程度、分子分型、T分期、人种亚组中，单因素分析显示，已婚患者5-CSS率均较未婚和不良婚姻患者高（均n P<0.001）；多因素分析显示，不良婚姻患者（除未分化型外）死亡风险均较已婚患者高（均n P<0.001），未婚患者（除未分化、Luminal B型、黑种人和其他人种外）死亡风险亦较已婚患者高（均n P<0.01）。n 结论:婚姻状况是早期乳腺癌患者生存的影响因素之一。“,”Objective:To investigate whether the real-world marital status is a factor affecting the survival of patients with early stage breast cancer.Methods:According to the data of 62 845 patients with early stage (Tn 1-2Nn 0Mn 0) breast cancer who received treatment from January 2012 to December 2015 in the Surveillance, Epidemiology and End Results (SEER) database, univariate survival analysis for 7 factors including age, race, surgery, T stage, tumor differentiation, molecular type and marital status was performed by Kaplan-Meier method. The 5-year cancer specific survival (5-CSS) rate was calculated. Multivariate Cox proportional hazards model was used to analyze the death risk of patients with different marital status (married, unmarried and bad marriage).n Results:Univariate analysis showed that 7 factors were correlated with the survival of patients with early stage breast cancer (all n P < 0.001). Multivariate analysis showed that marital status was an independent factor affecting the survival of patients, and the death risk of unmarried patients and patients with bad marriage was 2.014 times (95% n CI 1.714-2.367, n P < 0.001) and 2.559 times (95% n CI 2.254-2.905, n P < 0.001) higher than that of married patients, respectively. In tumor differentiation, molecular type, T stage and race subgroups, univariate analysis showed that the rates of 5-CSS in married patients were higher than those in unmarried patients and patients with bad marriage (all n P < 0.001); multivariate analysis showed that the risk of death in patients with bad marriage (except undifferentiated type) was higher than that in married patients (all n P < 0.001), and the risk of death in unmarried patients (except undifferentiation, Luminal B type, black and other races) was also higher than that in married patients (all n P < 0.01).n Conclusions:Marital status is one of the factors influencing the survival of patients with early stage breast cancer.