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锂治疗有时可发生甲状腺肿大和明显甲状腺功能过低,为了较详细确定锂引起丘脑下部-垂体-甲状腺(HPT)功能异常的发生率及性质,作者研究了21例接受碳酸锂治疗的精神病者,其中17例(男5、女12)平均年龄48岁,已平均用维持量锂治疗21个月(1～67月)。内14例做HPT功能试验2次以上,2次试验相距最少3个月。还有4例(男1、女3)平均年龄32岁,HPT功能检查于锂治疗开始前、治疗开始后1周和2周,以后每月1次直至6个月。锂剂量:每天用量250～2750毫克,分次给予。结果绝大多数接受锂治疗的精神病者促甲状腺素
In order to determine in more detail the incidence and nature of hypothyroidism-hypopituitarism-thyroid (HPT) dysfunction caused by lithium, 21 patients with psychosis treated with lithium carbonate may be treated with lithium therapy, sometimes with goiter and obvious hypothyroidism. Among them, 17 cases (male 5, female 12) were average 48 years old and had been maintained on average lithium for 21 months (from January to June). 14 cases of HPT function test to do more than 2 times, two trials at least 3 months apart. The other 4 patients (male 1 and female 3) had an average age of 32 years. HPT function tests were performed before the start of lithium treatment, 1 week and 2 weeks after the start of treatment, and once monthly until 6 months after the start of treatment. Lithium dose: 250 ~ 2750 mg daily dosage, graded. Results The vast majority of patients with mental disorders treated with thyroid stimulating hormone