目的:分析艾滋病合并周围型肺占位性病变患者的临床特征。方法:纳入2012年1月至2019年1月于广州市第八人民医院诊治的55例艾滋病合并周围型肺占位性病变患者。根据肺活组织病理检查结果分为分枝杆菌感染组、真菌感染组和肿瘤组，比较3组患者的临床特征、不同CD4n ＋T淋巴细胞计数所占比例和胸部计算机断层成像特征。3组间比较采用n χ2检验，两两比较采用Bonferroni方法校正检验水准，因为进行3次两两比较，所以检验水准取0.016 7。n 结果:55例艾滋病合并周围型肺占位性病变患者中，肺活组织病理检查结果为分枝杆菌感染14例，真菌感染12例，肿瘤病变15例；11例患者为混合病变，包括分枝杆菌合并真菌感染7例，肿瘤合并真菌和(或)分枝杆菌感染4例；慢性间质性炎3例。主要临床表现为发热、咳痰、乏力、体质量下降和浅表淋巴结肿大。分枝杆菌感染组、真菌感染组和肿瘤组患者症状/体征、白细胞计数、血红蛋白、丙氨酸转氨酶、肌酐等比较差异均无统计学意义(均n P>0.05)。3组患者接受抗反转录病毒治疗差异有统计学意义(n χ2＝15.165，n P0.016 7)。3组患者病灶内部钙化灶比较差异有统计学意义(n χ2＝8.524，n P＝0.004)；分枝杆菌感染组与真菌感染组＋肿瘤组比较差异有统计学意义(n χ2＝10.982，n P0.05). There was significant difference in anti-retroviral therapy (ART) acceptance among the three groups (n χ2=15.165, n P0.016 7). There was significant difference among the three groups in calcification focus (n χ2=8.524, n P=0.004), while there was no difference between the n Mycobacterium infection group and fungal infection+ tumor group (n χ2=10.982, n P<0.016 7).n Conclusions:Mycobacterium infection, fungal infection and tumor are the main types of peripulmonary occupational lesions in AIDS patients. The differential diagnosis could be made by combining with chest CT features, ART acceptance and CD4n + T lymphocyte level.n