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本文报道用卡巴醌-强的松龙(CQ-P)联合化疗治疗以前未经治疗的18例多发性骨髓瘤(MM)。病人和方法选择作治疗的病人骨髓中浆细胞增多达20%以上,有溶骨性骨损害,血清和/或尿有单克隆异常蛋白增多。CQ-P 方案:口服卡巴醌0.06mg/kg/d 及强的松龙1.5～2mg/kg/d,连续4天。根据血液学耐受性,每2～3周重复此方案治疗。溶骨性损害导致骨痛者用局部放射治疗,严重贫血者则输血,细菌感染时用抗生素治疗,必要时采用其它支持疗法。通常在重复此方案4～5次后评价疗效。结果 2例于开始治疗未达3个月即失去追踪而
This article reports the treatment of 18 previously untreated multiple myeloma (MM) with carbachol-prednisolone (CQ-P) in combination with chemotherapy. Patients and methods selected for treatment of patients with bone marrow increased by more than 20% of plasma cells, osteolytic bone damage, serum and / or urine increased monoclonal abnormal protein. CQ-P program: oral carbachol 0.06mg / kg / d and prednisolone 1.5 ~ 2mg / kg / d for 4 days. According to hematological tolerance, repeat this regimen every 2 to 3 weeks. Osseous osteomalacia results in local radiotherapy for osteolystic lesions, blood transfusions for severe anemia, antibiotics for bacterial infections, and other supportive therapies if necessary. Usually repeat the program 4 to 5 times after the evaluation of efficacy. Results Two patients lost their follow-up after less than 3 months of treatment