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目的 :探讨蛛网膜下腔出血 (SAH)后体感诱发电位 (SEP)、血清及脑组织一氧化氮 (NO)含量变化和银杏叶制剂 (GBE)的影响。方法 :对假手术对照组 ,模型组和GBE处理组大鼠检测 2 4h内局部脑血流量 (rCBF)、SEP和血清及脑组织NO含量动态变化。结果 :SAH后rCBF立即降低 ,在 2 4h内无恢复趋势。SEP潜伏期于SAH后 1h开始明显延长。血清和脑组织NO含量于SAH后 1h开始分别显著减少和明显增加 ,并持续 2 4h。GBE有效阻止上述病理性改变。结论 :SEP对SAH后脑缺血损害的判断有重要意义。血清NO减少、脑组织NO增加分别在脑血管痉挛发生及加重脑缺血损害中起重要作用。GBE通过逆转SAH后NO异常变化而减轻脑血管痉挛及其脑缺血性损伤
Objective: To investigate the changes of somatosensory evoked potential (SEP), serum and brain tissue nitric oxide (NO) and the effect of gingko leaf preparation (GBE) after subarachnoid hemorrhage (SAH). Methods: The regional cerebral blood flow (rCBF), SEP and NO levels in serum and brain tissues of rats in sham-operation control group, model group and GBE-treated group were detected. Results: The rCBF decreased immediately after SAH and no recovery trend within 24 h. SEP latency was significantly prolonged 1h after SAH. NO content in serum and brain tissue significantly decreased and significantly increased from 1 hour after SAH, respectively, and continued for 24 hours. GBE effectively prevent the pathological changes. Conclusion: SEP is of great significance in judging the cerebral ischemic damage after SAH. Reduced serum NO, increased NO in brain tissue play an important role in the occurrence of cerebral vasospasm and aggravate cerebral ischemia. GBE relieves cerebral vasospasm and its ischemic injury by reversing the abnormal changes of NO after SAH