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应用微血管摄影技术,特别在球结膜和视网膜上的研究表明,在最早期可发生糖耐量异常时的动力学改变。糖尿病的第一年是以血管扩张为特征,尤其在微循环的静脉端更为明显,同时伴血浆渗透性明显增加。这提示相对的组织缺氧。红细胞的2,3二磷酸甘油酸(2,3 DPG)浓度是在各种病理情况下组织水平调节释氧的重要代谢控制因素。糖尿病酮症酸中毒时
Studies using microvascular imaging, particularly on the bulbar conjunctiva and retina, have shown kinetic changes at the earliest stages of impaired glucose tolerance. The first year of diabetes is characterized by vasodilation, especially in the venous end of the microcirculation is more obvious, accompanied by significantly increased plasma permeability. This suggested that the relative tissue hypoxia. The concentration of 2,3 diphosphoglycerate (2,3 DPG) in erythrocytes is an important metabolic control factor at the tissue level to regulate oxygen release under various pathological conditions. Diabetic ketoacidosis