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Toll样受体4(TLR4)是脂多糖的天然受体,在调节急性炎症反应、细胞信号转导和细胞凋亡中起重要作用。在急性炎性反应和纤维化组织中TLR4表达增高,提示可能在组织的急性炎性反应,以及之后的纤维化过程中起重要作用。目前,TLR4在肝硬化、急性肺损伤和肺纤维化的发病机制以及治疗方面的研究取得了一定的进展,有望成为该类疾病治疗的新靶点。文章就TLR4在肝硬化和肺纤维化等疾病中的研究现状和发展前景作一综述。
Toll-like receptor 4 (TLR4), a natural receptor of lipopolysaccharide, plays an important role in the regulation of acute inflammation, cell signaling and apoptosis. TLR4 expression is elevated in acute inflammatory response and fibrosis, suggesting that it may play an important role in the tissue’s acute inflammatory response and subsequent fibrosis. At present, TLR4 has made some progress in the pathogenesis and treatment of cirrhosis, acute lung injury and pulmonary fibrosis, which is expected to become a new target for the treatment of such diseases. The article reviews the research status and development prospects of TLR4 in diseases such as liver cirrhosis and pulmonary fibrosis.