Titanium dioxide(TiO_2)porous ceramic pellets with three dimension nano-structure were prepared using nano TiO_2 powder.The TiO_2 porous ceramic pellets were composed of TiO_2 nanoparticles with 14-16 nm in diameter and had porosity of 74.85%.The mean pore size of the TiO_2 porous ceramic pellets was 20.73 nm and the main pore size ranged from 3 to 16 nm.The mass loss of the TiO_2 ceramic pellets was less than 5%after 20 d immersion in water.The antibacterial properties of the TiO_2 pellets were studied.The sterilization rate of Colibacillus(hospital polluted water with bacterium)can reach 99%after 3 h photocatalytic process and these TiO_2 pellets are easy to be re-activated and cyclically be used.The shaping mechanism and photocatalysis sterilization mechanism of the TiO_2 pellets were discussed.