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目的比较高-低氧放射治疗与低氧放射治疗食管癌的近远期疗效及毒副反应。方法将68例欲接受根治性放疗的食管癌患者随机分入高-低氧组和低氧组。所有患者均采用6 MV X线照射,DT 1.8～2.0 Gy/次,每周5次。高-低氧组在放疗时先后吸入高、低浓度氧,低氧组在放疗过程中吸入低浓度氧。观察两组患者的总有效率,1年、3年、5年生存率,放疗急性反应及晚期并发症。结果高-低氧组有效率高于低氧组(81.3%VS 54.5%,χ2=5.2976,P=0.0214),两组1年生存率无明显差异(71.9%VS 57.6%,χ2=1.4529,P=0.2281),但3年及5年生存率高-低氧组均高于低氧组(53.1%VS 27.3%,χ2=4.5241,P=0.0334;34.4%VS 12.1%,χ2=4.5324,P=0.0333)。两组的放疗急性反应及晚期并发症差异无统计学意义。结论高-低氧放射治疗食管癌在总有效率及3年、5年生存率方面均优于低氧放疗,放疗毒副反应无明显增加。
The purpose of relatively high - hypoxic radiotherapy and hypoxia radiation treatment of esophageal cancer in the short term effect and toxicity. Methods A total of 68 patients with esophageal cancer who underwent radical radiotherapy were randomly divided into hypoxia group and hypoxia group. All patients were treated with 6 MV X-ray, DT 1.8 ~ 2.0 Gy / time, 5 times a week. Hyperoxia - hypoxia group inhaled high and low concentrations of oxygen during radiotherapy, and inhaled low concentrations of oxygen during radiotherapy. The total effective rate, 1 year, 3 year, 5 year survival rate, acute response to radiotherapy and late complications were observed. Results The effective rate of hyperxia - hypoxia group was higher than that of hypoxia group (81.3% vs 54.5%, χ2 = 5.2976, P = 0.0214). There was no significant difference in one - year survival between the two groups (71.9% VS 57.6%, χ2 = 1.4529, P = 0.2281), but the 3-year and 5-year survival rates were higher in hypoxia group than those in hypoxia group (53.1% VS 27.3%, χ2 = 4.5241, P = 0.0334; 34.4% vs 12.1%, χ2 = 4.5324, 0.0333). There was no significant difference between the two groups in acute radiation and late complications. Conclusion High-low-oxygen radiation treatment of esophageal cancer is better than hypoxic radiotherapy in total effective rate and 3-year and 5-year survival rate, no significant increase in radiation side effects.