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目的探讨纳络酮用于慢性呼吸衰竭并肺性脑病的临床效果。方法回顾分析62例患者的临床资料。结果两组间总有效率差异无统计学意义(P<0.01);治疗组清醒时间明显短于对照组(P<0.01);与治疗前比,两组治疗后PaO2均明显升高(P<0.01),PaCO2均明显下降(P<0.01),两组间差异无统计学意义(P>0.05)。结论盐酸纳络酮能促进肺性脑病患者神志的恢复,改善肺通气,是治疗肺性脑病的有效方法,值得临床应用。
Objective To investigate the clinical effect of naloxone on chronic respiratory failure and pulmonary encephalopathy. Methods Retrospective analysis of 62 patients with clinical data. Results There was no significant difference in the total effective rate between the two groups (P <0.01). The awake time in the treatment group was significantly shorter than that in the control group (P <0.01), and PaO2 was significantly increased in both groups after treatment (P < 0.01), PaCO2 were significantly decreased (P <0.01), no significant difference between the two groups (P> 0.05). Conclusion Naloxone hydrochloride can promote conscious recovery of patients with pulmonary encephalopathy and improve pulmonary ventilation. It is an effective method for the treatment of pulmonary encephalopathy and is worthy of clinical application.