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近年来,基因扩增(Gene amplification)与肿瘤细胞耐药性关系的研究颇引人注目。因为它从基因水平上探讨了肿瘤细胞产生耐药性的分子基础。大量的研究表明,甲氨蝶呤(MTX)可引起肿瘤细胞的某些基因单位出现重复排列顺序,即发生基因扩增现象,因而使细胞的组分发生量和质的改变,进而对MTX 产生耐药性,限制MTX 作为抗肿瘤化疗药物的有效应用。甲氨蝶岭引起的基因扩增现象MTX 是一种抗叶酸代谢物,是通过干扰一
In recent years, the relationship between gene amplification and drug resistance in tumor cells has attracted a lot of attention. Because it discusses the molecular basis of tumor cell resistance at the genetic level. A large number of studies have shown that MTX can cause certain gene units of tumor cells to appear in a repetitive sequence, that is, gene amplification occurs, thereby causing changes in the amount and quality of cell components, and thus the generation of MTX. Drug resistance limits the effective use of MTX as an anti-tumor chemotherapy drug. The gene amplification phenomenon caused by Methotrexate MTX is an anti-folate metabolite that interferes with