自从苏联学者 A.B.维希涅夫斯基氏根据巴甫洛夫神经病理学说,应用封闭疗法治疗疾病以来,它的疗效得到了确实的证明.封闭疗法所使用的普罗卡因,本是局部麻醉药可卡因的代用品,因其毒性较可卡因小7—10倍,且常用也不易成瘾,故应用极广,尤其用作封闭疗法以来,更是加大了其使用范围。而普罗卡因的毒性作用及过敏反应,虽见诸文献教本,但临床病例 Its efficacy has been proven since the Soviet scholar AB Wichniewski, according to Pavlok’s neuropathology, has demonstrated that the curative effect of closed therapy has been proven, and the use of procaine, a local anesthetic, for cocaine Of substitutes, because of its toxicity 7-10 times smaller than cocaine, and commonly used is not easy to addiction, it is extremely wide range of applications, especially since the closure therapy, it is to increase its scope of use. The toxic effects of procaine and allergic reactions, although see the textbooks, but clinical cases