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目的分析医院大环内酯类抗生素的应用情况,为临床合理用药提供参考。方法统计2008年至2011年大环内酯类抗生素的用药数量与金额,采用限定日剂量法计算用药频度(DDDs)、限定日费用(DDC)以及消耗金额与DDDs的序号比。结果近4年来,DDDs、金额排名及序号比变化不大。克拉霉素和阿奇霉素的DDDs逐年上升,红霉素、琥乙红霉素、罗红霉素的DDDs较平稳,而地红霉素、乙酰螺旋霉素的DDDs逐年下降;DDC在0.78～15.84元之间,呈逐年下降趋势。结论医院大环内酯类抗生素应用基本合理,但仍应加强该类药品的应用管理,提高临床合理用药水平。
Objective To analyze the application of macrolide antibiotics in hospitals and provide references for clinical rational drug use. Methods The quantity and amount of macrolide antibiotics were calculated from 2008 to 2011. DDDs, DDCs, DDDs and DDDs were calculated by the defined daily dosage method. The results of the past 4 years, DDDs, the amount of rankings and serial numbers change little. The DDDs of clarithromycin and azithromycin increased year by year. The DDDs of erythromycin, erythromycin, erythromycin and roxithromycin were relatively stable, while the DDDs of erythromycin and acetylspiramycin decreased year by year. DDC was between 0.78 and 15.84 Between, showing a downward trend year by year. Conclusion The application of macrolide antibiotics in hospitals is basically reasonable, but the application management of such macadam should be strengthened and the level of clinical rational drug use should be raised.