新生儿缺氧缺血性脑病（HIE）是导致新生儿死亡及影响神经预后的严重疾病，发病机理较为复杂，目前难以找到有效的预防和治疗方法。大量临床研究和动物实验表明，脑缺氧缺血时兴奋性氨基酸（EAA）释放增加和（或）摄取减少，引起神经元ca’”超负荷，产生细胞毒性，最终导致细 Neonatal hypoxic-ischemic encephalopathy (HIE) is a serious disease that leads to neonatal death and affects neurological prognosis. The pathogenesis is complex and it is difficult to find effective prevention and treatment methods. A large number of clinical studies and animal experiments show that hypoxic-ischemic brain excitatory amino acid (EAA) increased release and / or decrease, causing neuronal ca ’"overload, resulting in cytotoxicity, eventually leading to fine