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血管内皮生长因子(VEGF)是一种能特异的作用于血管内皮细胞,促进血管生成的糖蛋白,可促进血管内皮的生长、增殖、迁移和分化,与宫颈癌的发生发展及放射治疗预后有密切关系。本文对VEGF的结构和功能、VEGF对血管的生成及VEGF在预测晚期宫颈癌放疗联合化疗疗效等方面的研究进展,做一综述。
Vascular endothelial growth factor (VEGF) is a glycoprotein that can act on vascular endothelial cells and promote angiogenesis. It can promote the growth, proliferation, migration and differentiation of vascular endothelial cells, and the occurrence and development of cervical cancer and the prognosis of radiation therapy. close relationship. This review summarizes the research progress on the structure and function of VEGF, the production of vascular endothelial growth factor (VEGF) and the efficacy of VEGF in predicting the efficacy of radiotherapy combined with chemotherapy for advanced cervical cancer.