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近年来,通过对洋地黄作用及药代动力学的研究证明,洋地黄的正性肌力作用与剂量呈线性关系;每日排泄量与体存量成比例,从而废除了作用“全或无”、代谢每日排泄量固定的传统概念,否定了饱和量疗法的基础。维持量地高辛疗法治疗充血性心力衰竭(简称心衰)普遍应用于临床,中毒发生率显著降低,但在易患因素的影响下仍有发生中毒者,本文对笔者所遇30例维持量地高辛中毒者进行临床分析,试图探讨易患因素。临床资料一、一般资料:本组病例均系充血性心力衰竭病人,男19例,女11例,年龄20～75岁,其中≥60
In recent years, through the study of digitalis effects and pharmacokinetics, digitalis positive inotropic effect and dose was linear; daily excretion and body stock in proportion to the abolition of the role of “all or nothing” Metabolism The traditional concept of a fixed amount of daily excretion negates the basics of saturation therapy. To maintain the amount of digoxin therapy for congestive heart failure (referred to as heart failure) is generally used in clinical, the incidence of poisoning was significantly reduced, but the risk factors are still under the influence of poisoning, the author of this I encountered 30 cases of maintenance Digoxin poisoning for clinical analysis, trying to explore the risk factors. Clinical data First, the general information: The patients were patients with congestive heart failure, 19 males and 11 females, aged 20 to 75 years, of which ≥ 60