普度大学诺贝尔奖金获得者 Herbert C Brown 和 Bakthan Singaram 通过烯烃的硼氢化反应,提供了得到100%光学纯度手征性烷基甲硼烷的简便方法。此法使用廉价的常用试剂引入光学活性中心和分离该甲硼烷。且 Brown 认为,现在可以将硼元素上的烷基转移到几乎所有具有合成意义的元素上,而没有明显的外消旋化。所以该新方法将大大简化各类手征 Herbert C Brown and Bakthan Singaram, recipients of the Nobel laureates at Purdue University, provided an easy way to obtain 100% optical purity chiral alkylborane by the hydroboration of olefins. This method uses inexpensive common reagents to introduce the optically active center and separate the borane. And Brown believes that it is now possible to transfer the alkyl on the boron element to almost any element of synthetic significance without significant racemization. So the new method will greatly simplify all kinds of chiral