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目的 探讨术后早期应用肠内营养治疗晚期结肠癌患者细胞因子水平的变化。方法 采用酶联免疫法测定肠内营养组和对照组外周血清中 IL- 2、IL- 2 R及 IL- 2 Rα水平。结果 晚期结肠癌术后早期肠内营养组治疗 1周后 ,机体细胞因子 IL - 2、IL - 2 Rα水平迅速上升 ,s IL - 2 Rα下降明显 ;而常规输液对照组 IL - 2、IL - 2 Rα水平迅速上升 ,s IL - 2 Rα下降明显 ;而常规输液对照组 IL- 2及 IL- 2 Rα水平呈下降趋势 ,s IL- 2 Rα变化不明显 ,两组结果相比差异显著 (P<0 .0 5或 P<0 .0 1)。结论 早期应用肠内营养治疗晚期结肠癌术后患者 ,有利于尽快恢复机体免疫调节功能 ,为临床今后开展对晚期结肠癌术后早期肠内营养治疗提供了实验证据
Objective To investigate the changes of cytokines in patients with advanced colon cancer treated with early postoperative enteral nutrition. Methods Enzyme-linked immunosorbent assay was used to determine the levels of IL-2, IL-2 R and IL-2 Rα in the serum of enteral nutrition group and control group. Results After 1 week of early postoperative enteral nutrition in patients with advanced colon cancer, IL-2 and IL-2 Rα levels in the body increased rapidly, and sIL-2 Rα decreased significantly. In contrast, IL-2 and IL-2 in the conventional infusion control group. 2 The level of Rα increased rapidly, sIL-2 Rα decreased significantly, while the level of IL-2 and IL-2 Rα in the conventional infusion control group showed a downward trend, and the change of s IL-2 Rα was not significant. The difference between the two groups was significant (P <0. 0 5 or P <0. 0 1). Conclusion Early application of enteral nutrition in the treatment of patients with advanced colon cancer is beneficial to restore the body’s immune regulation function as soon as possible, and provides experimental evidence for early postoperative enteral nutrition treatment for advanced colon cancer.