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观察nm2 3抑癌基因在结直肠癌的阴性表达与肿瘤临床病理特征的关系。方法 :72例原发性结直肠癌石蜡包埋标本 ,用免疫组织化学方法 (SP)测定。结果 :nm2 3在 72例结直肠癌标本中 5 4例表达阴性 ,占 75 %。nm2 3的阴性表达与病人性别。年龄和肿瘤分化程度无明显相关 (P >0 .0 5 )。而与结直肠癌的Dukes分期和淋巴转移显著相关 (P <0 .0 5 )。结论 :nm2 3基因在结直肠癌的浸润和淋巴转移过程中发挥了一定的作用。
To observe the relationship between the negative expression of nm23 tumor suppressor gene in colorectal cancer and clinicopathological features of the tumor. Methods: Seventy-two paraffin-embedded specimens of primary colorectal cancer were examined by immunohistochemistry (SP). Results: nm23 was negative in 54 of 72 colorectal cancer specimens, accounting for 75%. Negative expression of nm23 and patient sex. There was no significant correlation between age and tumor differentiation (P> 0.05). But significantly correlated with Dukes stage and lymph node metastasis of colorectal cancer (P <0.05). Conclusion: The nm23 gene plays a role in the invasion and lymph node metastasis of colorectal cancer.