根据目前标准的原则,早期多发性骨髓瘤(MM)在未显示病变进展或产生症状前无需进行常规细胞毒性化疗。本文着重观察单独应用小剂量α干扰素(α-IFN)对无症状,以往未经治疗、病变小的MM 及IgM 单克隆γ球蛋白病(MG)的治疗价值.29例患者中,23例为Ⅰ期MM,6例为IgMMG,经3～24个月观察均无疾病进展证据,所有病人骨髓检查均有单克隆性浆细胞及淋巴浆细胞浸 According to the current standard principles, early multiple myeloma (MM) does not require routine cytotoxic chemotherapy until the lesion progresses or symptoms develop. This article focuses on the treatment of asymptomatic, previously untreated and lesser-morbid MM and IgM monoclonal gammopathy (MG) with a single low-dose interferon alpha (IFN-α) alone.29 of 29 patients For stage I MM, 6 cases of IgMMG, no evidence of disease progression after 3 to 24 months of observation, all patients with bone marrow examination of monoclonal plasma cells and lymphocyte plasma leaching